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Galantamine Hydrobromide 1953-04-4 Pharma Raw Material White Crystalline Powder

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Galantamine Hydrobromide 1953-04-4 Pharma Raw Material White Crystalline Powder

Brand Name : DKY

Place of Origin : China

MOQ : 1kg

Price : $1-2/kg

Payment Terms : T/T, Western Union, MoneyGram

Supply Ability : 200 kgs per year

Delivery Time : 5-7 work days

Packaging Details : 1kg/bag or 25kg/drum

Model Number : 1953-04-4

CAS No : 1953-04-4

Molecular formula : c17h22brno3

Molecular weight : 368.27

EINECS No : 217-780-5

Melting point : 256 ° C

Specific rotation : d20-93.1 ° (C = 0.1015in 15mlh2o)

Refractive index : - 95 ° (C = 1.4, H2O)

Storage conditions : − 20 ° C

Solubility : sparinglysolubleinwaer, veryslightlysolubleinanhydrousethanol.it resolvesindulutesolutions of alkalihydroxides

Appearance : white crystalline powder, odorless, bitter, soluble in water, slightly soluble in ethanol, insoluble in acetone, chloroform, ether and benzene.

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pharmaceutical raw materials Galantamine Hydrobromide 1953-04-4 API Manufacturer made in China


Basic parameter:

1. Product Name: galantaminehydrobromide

2. Other names: galanthaminehci; galanthaminehydrobromidelycoremen1953-04-4; galanthaminehydrobromidecorissp; galanthamidehdromide; galanthaminehbr; galanthaminehydromide; galanthaminehdromide; galanthaminehydrobromideinjection; galanthaminehyromidum

3. CAS No.: 1953-04-4

4. Molecular formula: c17h22brno3

5. Molecular weight: 368.27

6. EINECS No.: 217-780-5

7. Melting point: 256 ° C

8. Specific rotation: d20-93.1 ° (C = 0.1015in 15mlh2o)

9. Refractive index: - 95 ° (C = 1.4, H2O)

10. Storage conditions: − 20 ° C

11. Solubility: sparingly soluble in waer, very slightly soluble in anhydrousethanol.it resolvesindulutesolutions of alkalihydroxides

12. Appearance: white crystalline powder, odorless, bitter, soluble in water, slightly soluble in ethanol, insoluble in acetone, chloroform, ether and benzene.


Structure:


Pharmacological effects:
Galantamine hydrobromide is a tertiary amino alkaloid and is a reversible competitive inhibitor of cholinesterase. With the deepening understanding of the pathogenesis of alzheimer's disease (AD), the study on the treatment of AD started in the early 1980s. In 1987, American scholar Bonnie et al. were the first to obtain the patent for the treatment of AD with galantamine hydrobromide. Since then, pharmacology, pharmacodynamics and pharmacokinetics experiments related to this have been carried out in various countries. The results showed that galantamine hydrobromide, as a second generation cholinesterase inhibitor, blocked the degradation of acetylcholine by this enzyme through competing with acetylcholine to bind with cholinesterase in the synapses, thus increasing the concentration of acetylcholine in the brain.
Indications:
It is suitable for benign memory disorder to improve patients' ability of pointing memory, associative learning, image recall, meaningless figure recognition and portrait recall. It also improves the memory impairment caused by dementia patients and brain temperament disease.
USES: 1. Used for motor disorders, multiple neuritis and spinal radiculitis caused by neurological diseases and trauma. 2. Cholinesterase inhibitor reverses scopolamine induced memory loss.

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