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HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder

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HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder

Brand Name : DKY

Model Number : 89778-27-8

Certification : COA

Place of Origin : hubei

MOQ : 10g

Payment Terms : T/T, Western Union, MoneyGram

Supply Ability : 200kg per year

Delivery Time : 5-7 work days

Packaging Details : 1kg/bag or 100g/bag

CAS no : 89778-27-8

Molecular formula : C26H28ClNO·C6H8O7

Molecular weight : 598.09

EINECS no : 663-344-6

Melting point : 160-162℃

Boiling point : 146-148℃

Density : 1045 g/cm3

Refractive index : 1,416-1,418

Storage condition : minus 20°C, Freezer

Solubility : DMSO: >10mg/mL

Appearance : White crystalline powder

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HPLC 99% purity Toremifene citrate/Fareston 89778-27-8 white powder
Basic parameter:
Product name: TOREMIFENE CITRATE
Product alias:
(z) - 4 - chloro - 1, 2 - diphenyl - 1 - (4 - (2 - (n, n - dimethylamino) ethoxy) phenyl) - 1 - butene; 2 - (4 - (4 - chloro - 1, 2 - diphenyl - 1 - butenyl) phenoxy] - n, n - dimethyl - ethanamin (z) - ethanamin; 2 - hydroxy - 1, 2, 3 - propanetricarboxylate (1:1); Fareston; Fc1157a; Nk622; (z) -, 2 - [4 - (4 - chloro - 1, 2 - diphenyl - 1 - butenyl) phenoxy] - n, n - dimethyl - ethanamine 2 - hydroxy - 1, 2, 3 - propanetricarboxylate; TROPISETRON CITRATE; 2 - (4 - [(z) 1-4 - CHLORO - 1, 2 - DIPHENYL - 1 - BUTENYL] PHENOXY] - N, N - DIMETHYLETHANAMINE;
CAS no. : 89778-27-8
Molecular formula: C26H28ClNO·C6H8O7
Molecular weight: 598.09
EINECS no. : 663-344-6
Melting point: 160-162℃
Boiling point: 146-148℃
Density: 1045 g/cm3
Refractive index: 1,416-1,418
Storage condition: minus 20°C, Freezer
Solubility: DMSO: >10mg/mL
Appearance: White crystalline powder
Certificate of Analysis:
PRODUCTToremifene citrateSPECIFICATIONRaw material
BATCH No.181007EXP.DATE2022.10
REFERENCEExport standardQUANTITY30.4 kg
Test itemsQuality requirementsResults
【DescriptionWhite or like white crystalline powderWhite crystalline powder
SolubilityFreely soluble in pyridine and acetic acid(100), sparingly soluble in methanol, slightly soluble in ethanol, very slightly soluble in water, and practically insoluble in diethyl etherFreely soluble in pyridine and acetic acid(100), sparingly soluble in methanol, slightly soluble in ethanol, very slightly soluble in water, and practically insoluble in diethyl ether
Melting point159.0~163.0℃159.5~161.0℃
Identification
(a)Positive reactionMust complyComplies
(b)Positive reactionMust complyComplies
(c) UVThere is the strongest absorption at the wavelength of 234~238nm and 275~278nm.There is the strongest absorption at the wavelength of 237nm and 277nm.
(d) IRThere is absorption at 1741, 1703, 1585, 1241 and 706cm-1 .There is absorption at 1741, 1703, 1585, 1241 and 706cm-1 .
Purity
(a) Relative substances
①E-isomer≤0.5%0,04%
②Total relative substances≤1.0%0.1%
(b)Heavy metals≤10ppm<10ppm
【Loss on drying】≤1.0%0.1%
Toluene≤0.089%0.3%
Acetone≤0.5%
【Residue on ignition】≤0.1%0.01%
Total bacteria quantity<100 cfu/g<10 cfu/g
Mold total yeast<20 cfu/g<10 cfu/g
Escherichia coliNo detectedNot detected
【Assay】≥98.5% (Calculated by C26H28ClNO .C6H8O7)100.0%
Conclusion: The results comply with the requirements of the export standard.

Product shooting:

Quick Detail:
Torremifen citrate binds to estrogen receptors and can produce estrogen-like or anti-estrogenic effects, or both, depending on the duration of treatment, animal species, sex and target organ. In general, nonsteroidal tristyrene derivatives are mainly antiestrogenic in humans and rats and estrogen-like in mice. Moderate decreases in serum total cholesterol and low density lipoprotein (LDL) were observed in postmenopausal breast cancer patients treated with torremifen. Chemicalbook and estrogen competitively bind to estrogen receptors in the cytoplasm of breast cancer cells, preventing estrogen-induced DNA synthesis and proliferation of cancer cells. The use of large doses of Torremifen citrate in some experimental tumors has shown that torremifen citrate has non-estrogen-dependent antitumor effects. The anti-breast cancer effect of Torremifen citrate is mainly the anti-estrogen effect, and there may be other anti-cancer mechanisms (change of tumor gene expression, secretion of growth factors, induction of apoptosis and influence of cell dynamics cycle).
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89778-27-8

      

Toremifene Citrate

      
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